A new manuscript from our collaborator Ines Liebscher and us is out on BioRxiv:
“Mimicking extracellular matrix-mediated mechano-activation by antibodies to control signaling of the adhesion G protein-coupled receptor GPR126/ADGRG6” click
Jakob, a visiting student from the Liebscher lab, has set up a technique together with Camilla to modulate adhesion-GPCR signaling by AFM force spectroscopy and to simultaneously monitor cAMP levels using a fluorescent sensor. In this study, they characterized the interplay of mechanical forces and signaling of GPR126.
Congratulations to both Jakob and Camilla!
Cell Adhesion Lab 