New lab member

After his internship in the lab last year, Ramón Castellanos decided to join the lab as a Postdoc and focus on projects in the cardiovascular system. Welcome Ramón!

New manuscript on BioRxiv

A new manuscript from Maitreyi Rathod in the lab is out on BioRxiv:
“Desmosomal cell cohesion and epidermal differentiation are modulated by dolichol phosphate mannosyltransferase 1 (DPM1) through SERPINB5-dependent mechanisms” Link to Manuscript

Maitreyi identified a novel regulatory function of the DPM complex for desmosomal adhesion which is relevant for epidermal differentiation.

Congratulations Maitreyi!

Poster presentation award

Marie has just received the poster award at the 115. Annual Meeting of the german Anatomical Society for her poster “Combining AFM-based functional imaging with fluorescence reporters to outline adhesion-dependent signaling”.
Congratulations Marie and thank you for presenting your work in such concise and convincing way!

New manuscript on BioRxiv

A new manuscript from our collaborator Ines Liebscher and us is out on BioRxiv:
“Mimicking extracellular matrix-mediated mechano-activation by antibodies to control signaling of the adhesion G protein-coupled receptor GPR126/ADGRG6” click

Jakob, a visiting student from the Liebscher lab, has set up a technique together with Camilla to modulate adhesion-GPCR signaling by AFM force spectroscopy and to simultaneously monitor cAMP levels using a fluorescent sensor. In this study, they characterized the interplay of mechanical forces and signaling of GPR126.

Congratulations to both Jakob and Camilla!

New Biorxiv manuscript

Camilla’s preprint is out! “Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade” click
Together with our colleagues form Cardiology, Bioinformatics and Legal medicine we generated and characterized a novel mouse model of Arrhythmogenic cardiomyopathy (ACM) based on defective desmosomal adhesion. We used this model to identify a novel pathway for fibrosis generation in ACM hearts.