After his internship in the lab last year, Ramón Castellanos decided to join the lab as a Postdoc and focus on projects in the cardiovascular system. Welcome Ramón!

A new manuscript from Maitreyi Rathod in the lab is out on BioRxiv:
“Desmosomal cell cohesion and epidermal differentiation are modulated by dolichol phosphate mannosyltransferase 1 (DPM1) through SERPINB5-dependent mechanisms” Link to Manuscript

Maitreyi identified a novel regulatory function of the DPM complex for desmosomal adhesion which is relevant for epidermal differentiation.

Congratulations Maitreyi!

Camilla published her paper on the role of desmosomal adhesion for Arrhythmogenic Cardiomyopathy in Circulation! Great work, and awesome team effort of all other lab member and the collaborators!

Link

Congratulations Jakob and Camilla for publishing the manuscript “The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator” ind Frontiers Cell and Developmental Biology!

Link

Karen Leal Fisher joined the Cell Adhesion Lab as PhD student! She will be part of the skin project. Welcome Karen!

Marie has just received the poster award at the 115. Annual Meeting of the german Anatomical Society for her poster “Combining AFM-based functional imaging with fluorescence reporters to outline adhesion-dependent signaling”.
Congratulations Marie and thank you for presenting your work in such concise and convincing way!

A new manuscript from our collaborator Ines Liebscher and us is out on BioRxiv:
“Mimicking extracellular matrix-mediated mechano-activation by antibodies to control signaling of the adhesion G protein-coupled receptor GPR126/ADGRG6” click

Jakob, a visiting student from the Liebscher lab, has set up a technique together with Camilla to modulate adhesion-GPCR signaling by AFM force spectroscopy and to simultaneously monitor cAMP levels using a fluorescent sensor. In this study, they characterized the interplay of mechanical forces and signaling of GPR126.

Congratulations to both Jakob and Camilla!

Pauline Hanns and Lea Galvagno just joined our lab as technician and general support, respectively. They will work together with Camilla in her project on the role of desmosomal adhesion in the heart. Welcome!!

Camilla’s preprint is out! “Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade” click
Together with our colleagues form Cardiology, Bioinformatics and Legal medicine we generated and characterized a novel mouse model of Arrhythmogenic cardiomyopathy (ACM) based on defective desmosomal adhesion. We used this model to identify a novel pathway for fibrosis generation in ACM hearts.

Congratulations!

Paul Marteau from France joined the Cell Adhesion Lab as PhD student! Similar to Marie, he will be part of the skin project. Welcome Paul!!

Vivien Beyersdorfer joined the Cell Adhesion Lab as PhD student! She will be part of the skin project. Welcome Vivien to our team!

Ramón Castellanos is a PhD student from our collaborator Michael Schnoor at CINVESTAV in Mexiko City. He will join our group for a couple of months. Welcome Ramón!

Marie’s manuscript on desmoplakin and its function in clustering of desmosomal cadherins is published! “Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion” click

Congratulations, great work!

Maitreyi Rathod from India just joined our team as Postdoctoral fellow. We wish you a good start in Switzerland and a lot of success in your project!
Welcome to the lab!

Jakob is a visiting student from the Liebscher lab and will do AFM force spectroscopy on adhesion GPCRs. Welcome!

Our new website is finally live. It will give an overview on our projects, publications and the people behind the work. Feel free to contact us!